The Crew-7 mission was commanded by American Jasmin Moghbeli and included Andreas Mogensen of Denmark, Satoshi Furukawa of Japan, and Konstantin Borisov of Russia.
The launch took place at 3:27 am (0727 GMT) from Launch Complex 39A at NASA's Kennedy Space Center in Florida.
The launch had been rescheduled to Saturday after engineers took an extra day to review a component of the Crew Dragon capsule's environmental control and life support system, NASA mentioned in a blog post.
It marked the maiden space mission for both Moghbeli and Borisov.
"Experiencing this has been a dream come true," Moghbeli, a Naval test pilot, commented in a recent media interaction.
"One of the highlights of the journey was gazing back at our beautiful planet," the 40-year-old of Iranian heritage remarked.
"Many who had flown before had mentioned that it offers a life-changing perspective-and floating around in space was truly exhilarating."
Crew-7 marked the seventh routine mission to the orbital platform for Elon Musk's SpaceX, with the first having been in 2020.
NASA compensates SpaceX for this taxi service under a commercial crew program, an initiative that was developed to lessen the dependency on Russian rockets for astronaut transport after the space shuttle program concluded in 2011.
Boeing remains the other private contract partner, but its efforts continue to face delays and technical challenges. It hasn't launched any crew thus far.
Borisov became the third Russian to journey on a SpaceX Crew Dragon capsule, which was mounted atop a Falcon 9 rocket.
Space endures as a unique domain of collaboration between the United States and Russia, even in light of Moscow's incursion into Ukraine, with Americans also journeying on Russian Soyuz rockets that take off from Kazakhstan.
The crew will be stationed for six months on the ISS, where they are set to undertake science experiments. This includes gathering samples during a spacewalk to ascertain if the station disperses microorganisms via its life support system vents.
The objective is to discern if microorganisms can endure and proliferate in space.
Another study is centered around identifying the physiological disparities between sleep on Earth and in space.
"Having confronted all the challenges, this profession is indeed fascinating. You prepare for something you've never experienced before, with the ambition to execute it flawlessly," Borisov reflected.
Crew-7 has joined the seven individuals already on the ISS, and soon, members of Crew-6 will be returning to Earth.
The ISS's inaugural segment was dispatched in 1998, and it has been perpetually occupied by an international contingent since 2001.
Plans for its operations extend until roughly 2030, after which it will be retired and descend into the ocean. Multiple private enterprises are progressing with plans for commercial space stations as successors.
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