Al-Masirah TV reported that "the US aggression launched 17 raids on the Saada governorate during the night", and earlier said two raids hit Amran.
The Iran-backed rebels' news agency, Saba, said "the American aggression targeted the Oncology Hospital building in Saada".
The hospital, which Huthi media said was under construction, was also hit last week.
The rebel health ministry said two civilians were wounded in the latest hospital attack, which they described as "a full-fledged war crime".
Early Wednesday, a Huthi military spokesperson said the group targeted "enemy warships in the Red Sea, led by the US aircraft carrier Truman" blamed for the Yemen strikes.
The rebels also claimed a drone attack on Tel Aviv, but did not specify when it occurred. Israel did not report such an attack.
Washington announced a military offensive against the Huthis on March 15, promising to use overwhelming force until the group stopped firing on vessels in the key shipping routes of the Red Sea and Gulf of Aden.
That day saw a wave of US air strikes that officials said killed senior Huthi leaders, and which the rebels' health ministry said killed 53 people.
Since then, Huthi-held parts of Yemen have witnessed near-daily attacks that the group has blamed on the United States, with the rebels announcing the targeting of US military ships and Israel.
The Huthis began targeting shipping vessels after the start of the Gaza war, claiming solidarity with Palestinians, but paused their campaign when a ceasefire took effect in Gaza in January.
Earlier this month, they threatened to renew attacks in the vital maritime trade route over Israel's aid blockade on the Palestinian territory, triggering the first US strikes on Yemen since President Donald Trump took office in January.
Last week, Trump threatened to annihilate the Huthis and warned Tehran against continuing to aid the group.
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